Past Defences

Thesis books

2016 |2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2001 | 2000 | 1999 | 1998 | 1997 | 1996 | 1995 |

Read Medical Genetics Graduate students’ theses on Circle.

2016

Doctoral
Kaurah, Pardeep Hereditary Diffuse Gastric: Cancer Risk and the Personal Cost of Preventative Surgery
Trinh, Joanne The Lysine Methyltransferase EHMT2/G9a in Mesenchymal Development
Yeung, Joanna The Role of Pax6 and Wls in Rhombic Lip Compartmentation and Cerebellar Development
Master’s
de Goede, Olivia Identifying Epigenetic Associations with Cell Type and Gestational Age in the Neonatal Immune System
Lee, Ka Young Functional Characterization of Gene Regulation by NHR-49
Pilsworth, Jessica Gene Expression and Mutation Profiles Define Novel Subclasses of Cytogenetically Normal Acute Myeloid Leukemia

2015

Doctoral
DeSouza, Rebecca Characterization of the Huntingtin Gene Promoter and Huntingtin Transcriptional Regulation
Heppner, Jonathan Early Disruption of the Extracellular Matrix in Murine Mucopolysaccharidosis I
Lin, David Tse-Shen Characterization of Novel Regulatory Components in the Dynamic Protein Palmitolytion Cycle
Tharmarajah, Grace The Role of Adamts9 in Melanoblast Migration and Modification of the Skin Proteome
Master’s
Ang, Sidney Identification and Characterization of Dosage Mutator Genes in Saccharomyces cerevisiae
Huff, Ryan Generation and Characterization of a Lysine (K)-specific Methyltransferase 2D Knockout Human Cell Line

2014

Doctoral
Esmailzadeh, Sharmin The role of BIN1 in the Regulation of Cell Proliferation, Apoptosis and Tumor Formation in Cutaneous T-Cell Lymphoma
Jett, Kimberly Vascular Function in Neurofibromatosis 1
Lee, Joshua Multiple Sclerosis in Asian Populations : The Genetic and Environmental Determinants of Variable Susceptibility and Clinical Profile
Miller, Michelle Validation of Two Novel Mouse Models of Conditional Meis1 Deletion to Study Roles in Adult Mouse Hematopoiesis
Poon, Anna Fong-Yee Genetic Architecture of Neurogenesis in the Adult Mouse Forebrain: Insights from Quantitative Trait Locus Analyses
Master’s
Billings, Raewyn Stimulating Human Tumour Heterogeneity using Cancer Cell Line Mixtures
Greenwood, Talitha Gene Discovery in Individuals from Families Indicative of Mendelian Forms of Late-Onset Alzheimer Disease
Huang, Jenny Li-Ying Ocular Melanocytes respond to Oncogenic GNAQQ209L differently compared to Epidermal and Dermal Melanocytes in Mice
Kaur, Achint The Role of Sterol 12α- hydroxylase (Cyp8b1) in Glucose Homeostasis
Lee, Jong Wook A Genome-Wide Association Study of Cisplatin-Induced Hearing Loss in Children
Moshgabadi, Noushin Identification of Synthetic Cytotoxic Interactions to Improve the Efficacy of DNA Damaging Therapeutic Agents
Tam, Annie Whole Genome Mutational Profiling of the Chemotherapeutic Agent Mitomycin C
Ye, Xin Mapping a New Locus for Non-Syndromic Strabismus with High-Throughput Genome Analysis

2013

Doctoral
Baradaran-Heravi, Alireza Schimke Immuno-osseous Dysplasia: Association of SMARCAL1 Mutations with Genetics and Environmental Disturbances of Gene Expression
de Leeuw, Charles Development of Tools in Mouse for Future Gene Therapy: Promoters for the CNS, and Novel Expression Models of Neural Stem Cell Regulator, NR2E1.
Hanna, Courtney Patterns of DNA Methylation on the Human X Chromosome and Use in Analyzing X-Chromosome Inactivation
MacIsaac, Julia Developmental Consequences of Imprinted Transcription at the Mest Locus
Mazarei, Gelareh Investigating the role of Indoleamine 2,3 dioxygenase in Huntington disease
Master’s
Blair, John  DNA methylation studies of preeclamsia and related conditions
Chapman, Andrew Transcriptional regulation of the XIST locus
Jacob, Karen The function of the imprinted transcription factor ASCL2 in mouse trophoblast development
Kelsey, Angela Mechanisms for XIST RNA cis-localisation
Stepien, Katarzyna Prenatal Alcohol Exposure Programs Steady-State Gene Expression and the Gene Expression Response to Inflammation in the Adult Rat Brain
Yoo, Janice The effects of cerebellar hemorrhage on the development of the postnatal cerebellum

2012

Doctoral
Cotton, Allison Patterns of DNA Methylation on the Human X Chromosome and Use in Analyzing X-Chromosome Inactivation
Earp, Madalene Genetic Studies to Discover Common Variants Associated with Epithelial Ovarian Cancer Risk and Variation in Age of Natural Menopause
Kang, Martin Post-transcriptional Regulation of ABCA1
Minks, Jakub Role of XIST RNA and Its Interacting Protein Partners in Gene Silencing
Semaka, Alicia Genetic Counselling Implications for Intermediate Allele Predictive Test Results for Huntington Disease
Master’s
Chowdhury, Miraj Tyrosyl-DNA Phosphodiesterase 1 (TDP1): A Rhabdomyosarcoma Therapeutic Target and Mitochondrial DNA Repair Enzyme
Chun, Stella Identification and validation of CDK13 interacting proteins
Fisher, Emily The Epidemiology of Huntington Disease in British Columbia
Fornika, Dan Mitochondrial Genome Variation and Healthy Aging
Lepage, Sarah Analysis of the Mechanism of Maintenance of the H3K27 Trimethylation Mark Using a Novel Chromatin Targeting System
Yang, Christine DNA methylation demonstrates spread of X-chromosome inactivation to human transgenes

 

2011

Doctoral
Burston, Helen Genome-wide Analysis of Endocytic Recycling inS. cerevisiae
Deo, Mugdha Role of Nf1 Signaling in Regulating Pigmentation in Mice
Lee, Connie The role of imprinted genes in mouse models of IUGR
Leung, Danny Transcriptional Silencing of Endogenous Retroviruses: Interplay Between Histone H3K9 Methylation and DNA Methylation
McLellan, Jessica A Cross Species Approach to Identify Potential Therapeutic Targets through Synthetic Lethal Interactions
Oh-McGinnis, Rosemary Regulation of Genomic Imprinting in the Mouse Placenta
Yuen, Ryan Epigenetics of Human Fetal and Placental Development
Master’s
Brind’Amour, Julie Analysis of the Mechanism of Maintenance of the H3K27 Trimethylation Mark Using a Novel Chromatin Targeting System
Decker, Michelle Telomere Length and Dynamics in Hutchinson-Gilford Progeria Syndrome
Miceli, Katharine Who’s the Boss? An Investigation into the Complex Relationship between Endogenous Retroviruses and Nearby Genes
Sekulovic, Sanja Analysis of the Mechanism of Maintenance of the H3K27 Trimethylation Mark Using a Novel Chromatin Targeting System

2010

Doctoral
Alwan, Sura Risk Assessment of Birth Defects in Human Pregnancy
Degeer, Donna Characterization of a Novel Fluorescent Reporter of Genomic Imprinting in the Mouse
Gallo, Marco Misc/OCG is a New Stress Response Gene and Regulator of Apoptosis, Germline Stem Cell Proliferation and Insulin Secretion
Jensen, Victor Novel Components of the Dauer Larva Developmental Signaling Pathway in Caenorhabditis elegans
Schuetz, Johanna Genetic Variation in Lymphocyte Life and Death Genes and Risk of non-Hodgkin Lymphomas
Jones, Meaghan XIST/Xist Induced Epigenetic Events in Somatic Cells
Long, Michael Development of Strategies to Enhance the Contribution of Hematopoietic Cells to Skeletal Muscle Repair.
Morrissy, Anca Bioinformatic Analysis of Cis-Encoded Antisense Transcription
Pouladi, Mahmoud On the Modulation of Excitotoxicity as a Therapeutic Approach for the Treatment of Huntington Disease
Thorogood, Nancy XIST/Xist Induced Epigenetic Events in Somatic Cells
Vrljicak, Pavel Genomic Analysis of Embryonic Heart Development in the Mouse
Young, Fiona The Biology and Expression of Huntingtin-Interacting Protein 14
Master’s
Bourque, Danielle Imprinted Genes in the Placenta and Obstetrical Complications
Degeer, Donna Characterization of a Novel Fluorescent Reporter of Genomic Imprinting in the Mouse
Hirukawa, Alison The role of SHIP1 in modulating disease severity in the K/BxN serum transfer model of rheumatoid arthritis
Huang, Jim  The characterization of atm-1 in Caenorhabditis elegans
Lohn, Zoe A New Role for the Tumour Suppressor, lin-35, During Meiotic Recombination in Caenorhabditis elegans
Ngai, Tiffany The Low-density Lipoprotein Receptor Knock-out Mouse: A Model for the Study of Energy Balance
Plamondon, Jenna Genetic and Epigenetic Factors in a Mouse Model for Multifactorial Cleft Lip
Thiele, Jenny Generation and characterization of embryonic stem cell lines derived from the YAC128 mouse model of Huntington disease

2009

Doctoral
Chang, Samuel Identification and characterization of cis-acting regulatory elements for human XIST
Griffith, Malachi Methods for Transcript Variant Discovery and Alternative Expression Analysis – Application to the Study of Fluorouracil Resistance in Colorectal Cancer
Haddon, Jamie Mast cells : homeostatic regulation, activation, gene expression, surface antigens, and role in allergic disease
Lam, Karen The role of palmitoylation in endoplasmic reticulum transport and quality control of the yeast polytopic protein Chs3
Pugh, Trevor Analysis of primary human cancers: from single genes to whole transcriptomes
Wong, Bibiana Evaluating the Effects of Variable NR2E1 Levels on Gene Expression, Behaviour, and Neural and Ocular Development
 Master’s
Borrie, Adrienne A mutational screen of NR2E1 in patients with Aniridia, Peters’ Anomaly, and related eye disorders.
Riendeau, Noemie Autism Spectrum Disorders: Identification of Novel Microdeletions and Microduplications and their Associated Phenotypes
Tkac, Jan Detection of Telomeric DNA Circles in Human ALT Cells Using Rolling Circle Amplification
Toub, Omid Initial characterization and Intracellular localization of two suppressors of position effect variegation in Drosophila melanogaster, S2214 and…

2008

Doctoral
Bretherick, Karla Genetic factors in premature ovarian failure
Griffith, Obi Identification of gene expression changes in human cancer using bioinformatic approaches
Rouhi, Arefeh A role for epigenetic modifications in the maintenance of mouse Ly49 receptor expression
Ryan, Jane A Genome-Wide Linkage Scan and Targeted Family-Based Association Analysis of Dyslexia
Master’s
Elves, Rachel Consequences of mitotic loss of heterozygosiy on genomic imprinting in mouse embryonic stem cells
Kennah, Erin Identification of differentially expressed genes in AHL-1-mediated leukemic transformation in human cutaneous T-cell lymphoma
Koochek, Maryam Sub-microscopic chromosomal imbalances in idiopathic autism spectrum disorder (ASD)
Mazarei, Gelareh Identification of Novel Striatal-Enriched Transcripts and their Analysis in Huntington Disease
Miller, Shelley Development of embryonic stem cells expressing endogenous levels of a fluorescent protein fused to the telomere binding protein TRF1
Wagner, Laura Silencing mutant huntington by RNA interference for the treatment of Huntington disease

2007

Doctoral
Bakovic, Silvia Ex vivo expansion of hematopoietic stem cells for use in nonmyeloablative transplantation
Brunham, Liam The impact of genetic variation in ABCA1 on cholesterol metabolism, atherosclerosis and diabetes
Tarailo, Maja Spindle assembly checkpoint and chromosome stability in Caenorhabditis elegans
Youds, Jillian Roles of the DOG-1 and JRH-1 helicase-like proteins in DNA repair in Caenorhabditis elegans
Master’s
Harbord, Sara X Chromosome Abnormalities in Breast and Ovarian Cancer

2006

Doctoral
Graham, Rona In vivo characterization of caspase resistant huntingtin: Insights into the pathogenic mechanism of Huntington disease
Kumar, Ravinesh Ex vivo expansion of hematopoietic stem cells for use in nonmyeloablative transplantation
Mar, Lynn Role of TGIF in cell cycle control and establishment of laterality
Nielsen, Julie The role of podocalyxin in adhesion and cell morphogenesis
Tucker, Tracy Pathogenesis of neurofibromatosis 1 associated neurofibromas
Yuen, Karen Identification and characterization of chromosome instability mutants in the yeast Saccharomyces cerevisiae and implications to human cancer
Master’s
Randall, Derrick Identification of a Serum Biomarker for Mucopolysaccharidosis
Sipahimalani, Payal Variation in ATM and genetic susceptibility to non-Hodgkin lymphoma
Quint, Desiree Aberrant Hypermethylation of Xq12 in Lymphoma
Wu, Joyce YB-1 is a Downstream Component of the PI3K/Akt Signaling Pathway and Regulates EGFR in Breast Carcinoma: A Mechanism for Breast Cancer…

2005

Doctoral
Cheng, Benjamin Identificaton of novel factors required for chromosome segregation in budding yeast
Cheung, Iris Instability of G-rich DNA in Caenorhabditis elegans
Gair, Jane Genetic mechanismss of nondisjunction in humans
Gurevich, Rhonna Functional analysis of the NUP98- Topoisoerase 1 (NUP98-TOP1) fusion gene in the pathogenesis of leukemia
Murray, Angus Functional genomics of the A600 locus in Leishmania mexicana
Pleasance, Erin Identification and analysis of programmed cell death genes in Drosophila melanogaster and human cancer using bioinformatic analysis of…
Van Raamsdonk, J. Characterization and treatment of mouse models in Huntington disease
Master’s
Schnerch, Angelique Analysis of Undifferentiated Human Embryonic Stem Cell Lines Using Serial Analysis of Gene Expression
Hoscheit, Julia Multifactorial genetics of exencephaly in the SELH/Bc mouse strain
Yen, Ziny Comparative sudies of X inactivation within Eutheria

2004

Doctoral
Dickstein, Dara The Role of Inflammation and amyloid beta in Alzeimer Disease Pathology

2003

Doctoral
Chopra, Vikramjit The HIP1 family of cytoskeletal-associated proteins
Chow, Jennifer XIST and its role in X-chromosome inactivation
Chu, Pak-Yan (Pat) Effect of c-kit and flt-3 overexpression on primitive hematopoietic cells
Penaherrera, Maria X-chromosome inactivation pattern in human extraembryonic and fetal tissues
Russell, Chris Transgenic expression of human alpha-L-iduronidase in mouse and characterization of the long term pathophysiology of murine alpha
Wilhelm, Brian The genomic organization and transcriptional regulation of natural killer receptor genes
MSc
Lee, Tsz Kin Bioinformatic analysis on NF1 transcriptional regulation

2002

Doctoral
Anderson, Cathy Variable X inactivation of the human TIMP1 gene
Faulkes, Sharlene Site-directed integration using the Cre/lox system in hematopoietic and embryonic stem cells
Master’s
Kwok, Ed XIST and macroH2A1.2 in hybrid cells

 

2001

Doctoral
Szudek, Jacek Analysis of variable expressivity in Neurofibromatosis
Parker, Jodey The Caenorhabditis elegans homologue of huntingtin interacting protein 1 has multiple roles in development

2000

Doctoral
Moslehi, Roxana Genetic studies of ovarian cancer in Jewish women

1999

Doctoral
Hodgson, John Production and characterization of YAC transgenic mice expressing the normal and mutant Huntington’s disease gene
Bruskiewich, R. Genetic mapping, functional analysis and bioinformatics of Werner syndrome locus (WRN)

1998

Doctoral
Gagne, Eric Identification and the relationship between mutations in the lipoprotein lipase gene, dyslipidemia and coronary heart disease
Nelson, Tanya Molecular and genetic analysis of human 8p inversion duplication chromosomes
Kowalski, Paul Novel genetic effects of a human endogenous retrovirus inserion

1997

Doctoral
Ginzinger, David Lipoprotein lipase deficiency in a colony of domestic cats

1996

Doctoral
Pawliuk, Robert Growth properties and genetic manipulation of murine hemopoietic stem cells

1995

Doctoral
Biaoyang, Lin Cloning and characterization of genes in the proximal candidate region for the Huntington disease in mouse and human