People

Genetics and epigenetics of human reproduction. Environmental effects on genes affecting placental function and fetal development. Epigenomics related to preeclampsia, intrauterine growth restriction, birth defects and early child development.

Dr. Sadovnick’s current research focuses on multiple sclerosis with particular emphasis on reproduction and child/maternal health.  She is also involved in family-based genetic studies and early onset familial Alzheimer’s disease.

Gene-based therapies for diseases of the brain and eye, cell-type specific MiniPomoters for rAAV delivery of gene augmentation and genome editing (CRISPR/cas9) therapies to cure mouse models of the human disease.

Computational analysis of human genome sequence for the study of gene regulation and rare pediatric disorders.

Studying inherited human disorders to understand human development, behaviour, physiology and degeneration. Emphasis on neurological, neuromuscular, and psychiatric diseases. The objective is to improve patient care.

High throughput data analysis, data standards, flow cytomety, GvHD biomarker identification, cluster identification.

Genetics of human cancer susceptibility, particularly lymphoma, and genetics of healthy aging and longevity. Family and population-based genetics studies. We use techniques such as genotyping and exome and whole genome sequencing.

Vesicle trafficking, lipid transport, yeast genetics, functional genomics, and mammalian cell biology.

Mammalian development, Transcriptional regulation and epigenetics, Hepatocyte differentiation, Heart valve formation, Signal transduction, Transgenic/knockout mice, Whole genome profiling

Gene regulation, leukemic stem cell biology, basic and translational leukemia research, signal transduction, proteomics.