Medical Genetics
Senior Scientist, Terry Fox Laboratory
Professor
Terry Fox Laboratory
BC Cancer Research Institute
675 West 10th Avenue
Vancouver, BC V5Z 1L3
Canada
fax: 6048770712
phone: 6046758135

Research Interests:

Research in the Lansdorp lab is focused on the role of genome instability in aging and cancer. For these studies we are mapping structural genomic variation such as polymorphic inversions of individuals onto their parental haplotypes using single cell DNA template strand sequencing (Strand-seq), a powerful technique developed in our lab1-6.

Recent Publications:

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View publications on PubMed

  1. Falconer E, Hills M, Naumann U, et al. DNA template strand sequencing of single-cells maps genomic rearrangements at high resolution. Nat Methods. 2012;9(11):1107-1112.
  2. Sanders AD, Falconer E, Hills M, Spierings DCJ, Lansdorp PM. Single-cell template strand sequencing by Strand-seq enables the characterization of individual homologs. Nat Protoc. 2017;12(6):1151-1176.
  3. Porubsky D, Garg S, Sanders AD, et al. Dense and accurate whole-chromosome haplotyping of individual genomes. Nat Commun. 2017;8(1):1293.
  4. van Wietmarschen N, Merzouk S, Halsema N, Spierings DCJ, Guryev V, Lansdorp PM. BLM helicase suppresses recombination at G-quadruplex motifs in transcribed genes. Nat Commun. 2018;9(1):271.
  5. Chaisson MJP, Sanders AD, Zhao X, et al. Multi-platform discovery of haplotype-resolved structural variation in human genomes. Nat Commun. 2019;10(1):1784.
  6. Sanders AD, Meiers S, Ghareghani M, et al. Single-cell analysis of structural variations and complex rearrangements with tri-channel processing. Nat Biotechnol. 2020;38(3):343-354.