X chromosome inactivation. Gene regulation, chromatin modification, epigenetic silencing.
Genetic epidemiology, statistical genetics, complex traits, neuropsychiatric disorders, population cohorts, electronic health records, biobanks.
Characterization of the stem cell state and its control by comparative global gene expression and proteomics analyses.
Mendelian disorders of body weight regulation and their relevance to common obesity and metabolic syndrome. Transgenic/knockout mice with perturbations of energy intake and energy expenditure. Weaver syndrome – mutation detection and new therapies. Clinical uses of next-generation sequencing for rare versions of common disease. Personalized Genomics.
Basic and translational leukemia research, Leukemic stem cell biology, Drug resistance, gene regulation and proteome dynamics, Oncolytic virotherapy and immunotherapy, Nonviral gene therapy
Our research focus is on the role of genome instability in aging and cancer. For these studies we have developed powerful single cell DNA template strand sequencing technique (Strand-seq). See: https://www.bccrc.ca/dept/tfl/people/peter-m-lansdorp
Role of imprinted genes in mammalian development. Epigenetics of embryonic stem cells and germ cell lineage. Gene targeting.
Interplay between transcription, DNA methylation and histone modifications in the germ line, early development and disease
Genetics and epigenetics related to fetal development and obstetrical complications of pregnancy such as fetal growth restriction, preterm birth, and birth defects. We use genomic and bioinformatic techniques/ tools to understand pathological processes related to placenta that affect the fetus and newborn.
Genome maintenance, DNA repair, RNA processing, DNA replication stress, Chromatin Remodelling, Stress responses, Protein quality control, Genotoxins, Saccharomyces cerevisiae, Mutation Signatures.
We study how transcriptional regulation affects metabolism and stress responses in C. elegans (worm), mice, and mammalian cells. Our goal is to identify genes and mechanisms that can be targeted in diseases such as cancers, diabetes, and neurodegenerative disorders, all of which have links to dysreguated stress response and metabolism. Our work is highly collaborative and uses state of the art genetic, genomic, molecular and computational biology approaches.
Computational analysis of gene regulation related to tissue development and rare pediatric disorders; development of databases and health informatics tools for improving diagnosis and support of individuals with genetic disease.