My laboratory studies include inherited disorders of lipid metabolism, premature cardiovascular disease, and pharmacogenomics. We use human genetics, animal models, and induced pluripotent stem cell models of disease.
Changes in specific genes that result in specific diseases, concentrating on Huntington disease and premature coronary artery disease.
Our research bridges the molecular mechanisms of epigenetic regulation with the social and environmental determinants of human health to develop a comprehensive understanding of biological embedding of early life experiences
Neurogenetics, Huntington disease and other triplet repeat disorders, transgenic/knockout mice, mouse models of human neurodegenerative disease, experimental therapeutics.
Computational analysis of human genome sequence for the study of gene regulation and rare pediatric disorders.