My laboratory studies include inherited disorders of lipid metabolism, premature cardiovascular disease, and pharmacogenomics. We use human genetics, animal models, and induced pluripotent stem cell models of disease.
We study the pharmacogenomics of drug response – particularly serious adverse drug reactions and the therapeutic failure of drugs. I have a particular interest in pediatric medicine and the variability in drug response.
Changes in specific genes that result in specific diseases, concentrating on Huntington disease and premature coronary artery disease.
Our research bridges the molecular mechanisms of epigenetic regulation with the social and environmental determinants of human health to develop a comprehensive understanding of biological embedding of early life experiences
Neurogenetics, Huntington disease and other triplet repeat disorders, transgenic/knockout mice, mouse models of human neurodegenerative disease, experimental therapeutics.