My laboratory studies include inherited disorders of lipid metabolism, premature cardiovascular disease, and pharmacogenomics. We use human genetics, animal models, and induced pluripotent stem cell models of disease.
Characterization of the stem cell state and its control by comparative global gene expression and proteomics analyses.
Changes in specific genes that result in specific diseases, concentrating on Huntington disease and premature coronary artery disease.
Mammalian development, Transcriptional regulation and epigenetics, Hepatocyte differentiation, Heart valve formation, Signal transduction, Transgenic/knockout mice, Whole genome profiling
Basic and translational leukemia research, Leukemic stem cell biology, Drug resistance, gene regulation and proteome dynamics, Oncolytic virotherapy and immunotherapy, Nonviral gene therapy
Our research focus is on the role of genome instability in aging and cancer. For these studies we have developed powerful single cell DNA template strand sequencing technique (Strand-seq). See: https://www.bccrc.ca/dept/tfl/people/peter-m-lansdorp
Neurogenetics, Huntington disease and other triplet repeat disorders, transgenic/knockout mice, mouse models of human neurodegenerative disease, experimental therapeutics.
Role of imprinted genes in mammalian development. Epigenetics of embryonic stem cells and germ cell lineage. Gene targeting.
iTARGET-Autism research is subgrouping “The Autisms” via whole phenome, genome, metabolome, microbiome and proteome discoveries in a precision medicine focus on autism cause, not only its symptoms.
Interplay between transcription, DNA methylation and histone modifications in the germ line, early development and disease
Neural stem cells; Neurotrophin regulation of neuronal survival, growth and connectivity; Role of p53 family in the nervous system; Molecular regulation of neurogenesis
Gene-based therapies for diseases of the brain and eye, cell-type specific MiniPomoters for rAAV delivery of gene augmentation and genome editing (CRISPR/cas9) therapies to cure mouse models of the human disease.
Computational analysis of gene regulation related to tissue development and rare pediatric disorders; development of databases and health informatics tools for improving diagnosis and support of individuals with genetic disease.
We are a stem cell bioengineering lab that develops robust technologies to control propagation and fate of stem cells and their derivatives, primarily focusing on blood differentiation from pluripotent stem cells.