See Graduate and Postdoctoral Studies website for further information on Medical Genetics Faculty potential supervisors.
Faculty Research Summaries List
Using the latest next-generation sequencing technology and bioinformatics methods to sequence and analyse the genomes and transcriptomes of human breast cancers.
1) exploring the genetic causes and understanding the clinical presentation of genetic conditions (Long QT Syndrome and Primary Biliary Cirrhosis, PBC) p revalent in BC First Nations; 2) exploring the determinants of early Inuit health and infant mortality; 3) understanding the effects of the environment and other determinants on birth outcomes in BC, Yukon, Alberta, and Nunavut.
The overall objective of my program of research is to use a clinical genetics perspective to inform the development of novel biological and non-biological interventions to improve outcomes for individuals with psychiatric disorders and to support their families.
Bioinformatics, sequence assembly, transcriptomics, gene regulation networks, high throughput informatics for big data. Birol Lab is located at British Columbia Cancer Agency, Genome Sciences Centre.
High throughput data analysis, data standards, flow cytomety, GvHD biomarker identification, cluster identification.
Genetics of human cancer susceptibility, particularly lymphoma, and genetics of healthy aging and longevity. Family and population-based genetics studies. We use techniques such as genotyping and exome and whole genome sequencing.
X chromosome inactivation. Gene regulation, chromatin modification, epigenetic silencing.
Ethical and social dimensions of genetic testing, knowledge, commercialization; democratizing the governance of genomics.
Vesicle trafficking, lipid transport, yeast genetics, functional genomics, and mammalian cell biology.
Characterization of the stem cell state and its control by comparative global gene expression and proteomics analyses.
Human pedigree and population genetics, and mouse modeling of neurodegenerative disease – designed to inform therapeutic development.
Clinical applications of genomic technology; birth defects epidemiology and clinical teratology; clinical studies of neurofibromatosis.
Mendelian disorders of body weight regulation and their relevance to common obesity and metabolic syndrome. Transgenic/knockout mice with perturbations of energy intake and energy expenditure. Weaver syndrome – mutation detection and new therapies. Clinical uses of next-generation sequencing for rare versions of common disease. Personalized Genomics.
Neurological mutant mice are used as entrees into studying the genetics, cell biology and development of genes that are critical to nervous system development.
Changes in specific genes that result in specific diseases, concentrating on Huntington disease and premature coronary artery disease.
Molecular biology of eukaryotic chromosome transmission, cancer therapeutics, model organism and human disease.
Mammalian development, Transcriptional regulation and epigenetics, Hepatocyte differentiation, Heart valve formation, Signal transduction, Transgenic/knockout mice, Whole genome profiling
Genetic control and manipulation of hemopoiesis. Stem Cell Regulation. Retroviral Gene Transfer. Transgenic Mice.
Gene regulation, leukemic stem cell biology, basic and translational leukemia research, signal transduction, proteomics.
Bioinformatics, gene expression, gene regulation, genome sequence analysis and genome assembly.
Our research bridges the molecular mechanisms of epigenetic regulation with the social and environmental determinants of human health to develop a comprehensive understanding of biological embedding of early life experiences
Stem cells, developmental control, telomere biology, self-renewal and genetic instability.
Neurogenetics, Huntington disease and other triplet repeat disorders, transgenic/knockout mice, mouse models of human neurodegenerative disease, experimental therapeutics.
Role of imprinted genes in mammalian development. Epigenetics of embryonic stem cells and germ cell lineage. Gene targeting.
Discovery of monogenic causes of human developmental or metabolic disorders; natural history of monogenic disorders; optimal management of mitochondrial disorders.
Genetic, genomic and comprehensive phenotyping studies for the autism spectrum disorders, idiopathic intellectual disabilities and other complex disorders of neurodevelopmental and/or behavioral disability.
Interplay between transcription, DNA methylation and histone modifications in embryonic stem cells and tumorigenesis.
Gene regulatory changes in malignancy, impact of transposable elements on mammalian genes, role of DNA methylation/epigenetics in gene expression.
Immunogenetics and Molecular Immunology. Cell surface proteins and Leishmania. Modulation of macrophage gene expression by M. tuberculosis.
Proteomics, protein-protein interactions, protein isoform function, alternative splicing.
The immune response to cancer; development of immunotherapies targeting the cancer genome.
Chromosomal etiology of intellectual disability/autism and cancer, Molecular cytogenetics, Identification of subtle chromosomal abnormalities using whole genome arrays
Genetics and epigenetics of human reproduction. Environmental effects on genes affecting placental function and fetal development. Epigenomics related to preeclampsia, intrauterine growth restriction, birth defects and early child development.
Dr. Sadovnick’s current research focuses on multiple sclerosis with particular emphasis on reproduction and child/maternal health. She is also involved in family-based genetic studies and early onset familial Alzheimer’s disease.
1) Scope and impact of germline findings identified in next generation sequencing and the use of these technologies in oncology; 2) molecular diagnosis and characterization of hereditary cancer syndromes
Gene-based therapies for diseases of the brain and eye, cell-type specific MiniPomoters for rAAV delivery of gene augmentation and genome editing (CRISPR/cas9) therapies to cure mouse models of the human disease.
Genome maintenance, DNA repair, RNA processing, DNA replication stress, Chromatin Remodelling, Stress responses, Protein quality control, Genotoxins, Saccharomyces cerevisiae, Mutation Signatures.
We study how transcriptional regulation affects metabolism and stress responses in C. elegans (worm), mice, and mammalian cells, to identify mechanisms that can be targeted in diseases such as cancers, diabetes, and neurodegenerative disorders.
My research is focused on the identification of the molecular components implicated in highly prevalent neurological diseases; including multiple sclerosis and essential tremor by utilizing the characterization of multi-incident families and large multi-ethnic populations from around the globe.