- Research Scientist, BC Mental Health and Addictions Research Institute, Vancouver.
- Centre Investigator, Brain Research Centre, University of British Columbia,Vancouver.
- Dr. Austin is jointly appointed between psychiatry and medical genetics.
Psychiatric disorders (e.g. depression, schizophrenia, bipolar disorder) are common conditions that are associated with extreme emotional burden, both for affected individuals and their families. Psychiatric disorders are complex conditions that arise as a result of combinations of genetic and environmental vulnerability factors. The genetics of psychiatric disorders is especially complex, so our understanding has been slow in coming despite application of state-of-the-art tools and a large number of studies over many years. Although both molecular genetic research in psychiatry and clinical applications of genetics in many other medical disciplines are well established, research involving clinical applications of genetics in psychiatric conditions is still emerging. However, progress is now being made, and there is an urgent need to translate this into benefit for individuals with psychiatric disorders and their families.
The overall objective of my program of research is to use a clinical genetics perspective to inform the development of novel biological and non-biological interventions to improve outcomes for individuals with psychiatric disorders and to support their families.
I am particularly interested in:
- Improving outcomes for people with mental illness and their families by helping them to better understand the causes of mental illness.
- Contributing to a better understanding of factors that contribute to the development of postpartum depression, and developing new nutritional interventions to reduce women’s risk for postpartum depression
- Modifying healthcare professionals attitudes towards individuals with mental illness.
Austin J. Evidence based genetic counseling for psychiatric disorders: a road map. Perspectives in Medicine in July 2019.
Lazaro-Munoz G, Sabatello M, Huckins L, Peay H, Degenhardt F, Meiser B, Lencz T, Soda T, Docherty A, Crepaz-Keay D, Austin J, Peterson R, Davis L. International Society of Psychiatric Genetics Ethics Committee: Issues Facing Us American Journal of Medical Genetics B Online early May 2019.
Semaka A, Austin J. An “empowering encounter”: the process and outcome of psychiatric genetic counseling. Journal of Genetic Counseling, 2019, 28(4): 856-58.
Moldovan R, McGhee KA, Coviello D, Hamang A, Inglis A, Ingvoldstad C, Laurino M, Meisser B, Rovira Moreno E, Murphy L, Paneque M, Papsuev O, Pawlak J, Shkedi S, Serra C, Soller M, Virkijk N, Voelkel MA, Watson M, Austin J. Psychiatric genetic counseling. A mapping exercise. American Journal of Medical Genetics: Part B in press Feb 2019.
Morris E, Slomp C, Hippman C, Inglis A, Carrion P, Batallones R, Andrighetti H, Austin J. A matched cohort study of postpartum placentophagy: impact on mood, energy, vitamin B12 levels, and lactation. Journal of Obstetrics and Gynecolocy Canada, 2019, 41(9): 1330-7.
Morris E, Best J, Inglis A, Austin J. Impact of the physical environment on patient outcomes of genetic counseling: an exploratory study. Journal of Genetic Counseling 2019, 28(4): 760-6.
Bulik CM, Blake L, Austin J. Eating disorders genetics: what the clinician needs to know. Psychiatric Clinics of North America 2019, 42(1):59-73.
Salema D, Townsend A, Austin J. Patient decision-making and the role of the prenatal genetic counsellor: an exploratory study. Journal of Genetic Counseling 2019, 28(1):155-163.
Cantor A, Hippman C, Hercher L, Austin J. Genetic counseling students’ mental health: an exploratory study. Journal of American College Health 2019. 67(4), 348-56.
Nurnberger J, Austin J, Berrettini W, Besterman AD, DeLisi L, Grice D, Kennedy J, Moreno-De-Luca D, Potash JB, Ross D, Schulze T, Zai G. What should a psychiatrist know about genetics? Review and Recommendations from the Education Taskforce of the International Society of Psychiatric Genetics. Journal of Clinical Psychiatry 2018, 27;80(1), pii: 17nr12046.
Borle K, Morris E, Inglis A, Austin J. Risk communication in genetic counselling: exploring uptake and perception of recurrence numbers, and their impact on patient outcomes. Clinical Genetics, 2018, 94(2): 239-45.
Ormond K, Wessels T, Barlow-Stewart K, Macauley S, Laurino M, Austin J, Middleton A. Genetic counseling globally: Where are we now? American Journal of Medical Genetics Part C. 2018, 178(1): 98-107.
Morris E, Hippman C, Murray G, Michalak E, Boyd JE, Livingston J,Inglis A, Carrion P,Austin J. The SSRMI scale: development and validation of a self-stigma measure for first-degree relatives of people with mental illness. British Journal of Psychiatry, 2018, 212(3): 169-74.
Slomp C, Morris E, Inglis A, Lehman A, Austin J. Patient outcomes of genetic counseling: assessing the impact of different approaches to family history collection. Clinical Genetics, 2018, 93(4):830-6.
Chen, B, Carrion P, Grewal R, Inglis A, Hippman C, Morris E, Albert A, Austin J. Short interpregnancy intervals, maternal folate levels and infants born small for gestational age: a preliminary study in a Canadian supplement using population. Applied Nutrition Physiology and Metabolism, 2017, 42(10):1092-1096.
Andrighetti H, Semaka A, Austin J. Women’s experiences of participating in a prospective, longitudinal postpartum depression study: insights for perinatal mental health researchers. Archives of Women’s Mental Health 2017 20(4) p547-59.
Moldovan R, Pintea S, Austin J. The effectiveness of genetic counseling for psychiatric disorders: a meta-analysis. Journal of Genetic Counseling 2017, 26(6):1341-1347.
Kalb F, Vincent V, Herzog T, Austin J. Genetic Counseling for Alcohol Addiction: Assessing Perceptions and Potential Utility in Individuals with Lived Experience and Their Family Members. Journal of Genetic Counseling 2017 Oct;26(5):963-970.
Austin J, Smith G.N., and Honer W. The genomic era and families’ perceptions of psychotic disorders: Genetic risk estimation, associations with reproductive decisions and views about predictive testing. American Journal of Medical Genetics: Neuropsychiatric Genetics 2006.141(8) p926-928.
Austin J. and Peay, H.L. Applications and Limitations of Empiric Data in Provision of Recurrence Risks for Schizophrenia: A practical review for healthcare professionals providing clinical psychiatric genetics consultations. Clinical Genetics 2006. 70 (3) p177-187.
Austin JC, and Honer WG. The genomic era and serious mental illness: a potential application for psychiatric genetic counseling. Psychiatric Services 2007. 58(2) p254-261.
Peay HL, Palmer C, Sheidley B, McCarthy Veach P, Gettig B, Austin JC. Psychiatric disorders in clinical genetics I: Assessing family histories of psychiatric disorders. Journal of Genetic Counseling 2008 17(1) p6-17.
Austin JC, Palmer C, Sheidley B, McCarthy Veach P, Gettig B, Peay HL. Psychiatric disorders in clinical genetics II: Individualizing recurrence risks for psychiatric disorders. Journal of Genetic Counseling 2008 17(1) p18-29.
Austin JC, and Honer WG. Psychiatric genetic counseling for parents of individuals with psychotic disorders: a pilot study. Early Intervention in Psychiatry 2008 2 p80-89.
Hippman C, Oberlander T, Honer WG, Misri S, Austin JC. Depression during pregnancy: the impact on maternal mood of increased risk for fetal aneuploidy. Clinical Genetics 2009 75 p30-36.
Monaco L, Conway L, Valverde K, and Austin JC. Genetic counselors’ perceptions and practices relating to schizophrenia. Public Health Genomics. 2010 13: 21-26.
Hunter, MJ, Hippman, C, Honer, WG, Austin JC. Genetic counseling for schizophrenia: a review of referrals to a provincial medical genetics program from 1968-2007. Am J Med Genet A, 2010 0(1): 147-152.
Austin, J.C. Re-conceptualizing risk in genetic counseling: implications for clinical practice. Journal of Genetic Counseling, 2010, 19(3): 228-34.
Devlin AM, Brain U, Austin JC, Oberlander TF. Maternal MTHFR C677T genotype & depressed mood during pregnancy affects SLC6A4 methylation in infants at birth PLOS 1 2010, 5(8):e12201.
Feret H, Conway L, Austin JC. Genetic Counselors’ attitudes towards individuals with schizophrenia: desire for social distance and endorsement of stereotypes. Patient Education and Counseling 2011 82: 69-73
McBride R, Austin JC. Sex testing or gender verification: is there a difference and does it matter? Journal of Genetic Counseling, 2011 20:113-114.
Peay and Austin. How to talk with families about genetics and psychiatric illness. W.W. Norton. 2011.
Zierhut H, Austin JC. How inclusion of genetic counselors on the research team can benefit translational science. Science Translational Medicine. 2011, 3(75): 75-76.
Chan RCK. Austin JC*, Pearson VJ, Gong Q, HonerWG. Translating genomic research into care for people with schizophrenia in China. Schizophrenia Research, 2011, 131:31-34.
Anderson K., Austin JC. Influencing genetic counselors’ attitudes towards people with mental illness: a pilot study. Journal of Genetic Counseling. 2012, 21: 573-81.
Hippman C., Inglis, A., Austin JC. What is a “balanced” description? Insight from parents of individuals with Down syndrome. Journal of Genetic Counseling. 2012, 21(1): 35-44.
Lautenbach, D., Hiraki, S., Whalen Campion, M., Austin, J.C. Mothers’ perspectives on their child’s mental illness as compared to other complex disorders in their family: insights to inform genetic counseling practice. Journal of Genetic Counseling. 2012, 21: 564-72.
Inglis A, Hippman C., Austin JC. Prenatal testing for Down Syndrome: Perspectives of parents of affected individuals. American Journal of Medical Genetics 2012, 158A (4), 743-50.
Austin JC, Hippman, C, and Honer, WG. Descriptive and numeric estimation of risk for psychotic disorders among affected individuals and relatives: implications for clinical practice. Psychiatric Research 2012, 196(1) 52-6.
Morris E, Inglis A, Friedman J, Austin JC: Discussing the psychiatric manifestations of 22q11.2 deletion syndrome: an exploration of clinical practice among medical geneticists. Genetics in Medicine. 2013 15, 713-720.
Yaremco E, Inglis A, Innis S, Hippman C, Carrion, P, Lamers Y, Honer WG, Austin JC. Red Blood cell Folate concentrations in pregnant women with a history of mood disorders: a case series. Birth Defects Research Part A, 2013 97(6), 416-420.
Hippman C, Lohn Z, Inglis A, Ringrose A, Cheek A, Austin JC. “Nothing is absolute in life:” Understanding uncertainty in the context of psychiatric genetic counseling from the perspective of those with serious mental illness. Journal of Genetic Counseling 2013 22(5) 625-632.
Maio M, Carrion P, Yaremco E, Austin JC. Awareness of genetic counseling and perceptions of its purpose: A survey of the Canadian public. Journal of Genetic Counseling 2013, 22(6) 762-770.
Inglis A, Hippman C, Carrion P, Honer WG, Austin JC. Mania and depression in the perinatal period among women with a history of major depressive disorders. Archives of Women’s Mental Health 2014, 17(2) 137-43.
Ashtiani S, Makela N, Carrion P, Austin J. Parents’ Experiences of Receiving their Child’s Genetic Diagnosis: A Qualitative Study to Inform Clinical Genetics Practice. American Journal of Medical Genetics 2014, 164(6) 1496-1502.
Lohn Z, Inglis A, Austin J, and Hippman C. A ‘cure’ for Down syndrome: What do parents want? Clinical Genetics 2014. 86(4):310-7.
Austin J, Semaka A, Hadjipavlou G. Conceptualizing genetic counseling as psychotherapy in the era of genomic medicine. Journal of Genetic Counseling 2014. 23(6) 903-909.
Inglis A, Koehn D, McGillivray B, Stewart E, Austin J. Evaluating the first specialist clinical psychiatric genetic counseling service: uptake and impact. Clinical Genetics 2015, 87(3) 218-224.
Ke S, Lai L, Sun T, Yang M, Wang JCC, Austin JC. Healthy Young Minds: The Effects of a One-hour Classroom Workshop on Mental Illness Stigma in High School Students. Community Mental Health Journal, 2015, 51(3):329-37.
Talcott-Baughman S, Morris E, Jensen K, Austin J. Disclosure of psychiatric manifestations of 22q11.2 deletion syndrome in medical genetics: a 12 year retrospective chart review. Am J Med Genet 2015, 167(10):2350-6.
Ryan J, Virani A, Austin J. Ethical issues associated with genetic counselling in the context of adolescent psychiatry. Appl Transl Genomics 2015, 5(1):23-9.
Austin J. The effect of genetic test-based risk information on behavioural outcomes: a critical examination of failed trials and call to action. Am J Med Genet. 2015,167(12):2913-5.
Hippman C, Ringrose A, Inglis A, Cheek J, Albert AY, Remick R, Honer WG, Austin JC. A pilot randomized clinical trial of the impact of genetic counseling for individuals with serious mental illness. J Clin Psych 2016, 77(2):e190–e198.
Mighton C, Inglis A, Carrion P, Hippman C, Morris E, Andrighetti H, Batallones R, Honer W, Austin J. Perinatal psychosis in mothers with a history of major depressive disorder. Arch Women Ment Health 2016;19(2):253-8.
Austin JC. 2020 Vision: Genetic Counselors as the recognized leaders in the integration of genetics and genomics into healthcare (Incoming presidential address). J Genet Couns. 2016. 25(1) 1-5.
Biesecker B, Austin J, Caleshu C. Theories for psychotherapeutic genetic counselling: Fuzzy trace theory and cognitive behavior theory. J Genet Couns. 2017; 26(2) 322-30.