Department of Medical Genetics, University of British Columbia
Michael Smith Laboratories
2185 East Mall
The University of British Columbia
Vancouver, B.C. V6T 1Z4
phone: 6048225936

Research Interests:

Molecular biology of eukaryotic chromosome transmission, cancer therapeutics, model organism and human disease.

Selected Publications:

Hieter, P., Boycott, K.M. (2014). Understanding rare disease pathogenesis: a grand challenge for model organisms. Genetics 198(2):443-5.

Chan, Y.A., Hieter, P., Stirling, P.C. (2014). Mechanisms of genome instability induced by RNA-processing defects. Trends Genet. 30(6):245-53.

Chan, Y.A., Aristizabal, M.J., Lu, P.Y., Luo, Z., Hamza, A., Kobor, M.S., Stirling, P.C., Hieter, P. (2014). Genome-wide profiling of yeast DNA:RNA hybrid prone sites with DRIP-chip. PLoS Genet. 10(4):e1004288.

Li, X., O’Neil, N.J., Moshgabadi, N., Hieter, P. (2014). Synthetic Cytotoxicity: Digenic Interactions with TEL1/ATM Mutations Reveal Sensitivity to Low Doses of Camptothecin. Genetics 197(2):611-23.

Huang, Y., Minaker, S., Roth, C., Huang, S., Hieter, P., Lipka, V., Wiermer, M., Li, X. (2014). An E4 ligase facilitates polyubiquitination of plant immune receptor resistance proteins in Arabidopsis. Plant Cell 26(1):485-96.

Bailey, M.L., O’Neil, N.J., van Pel, D.M., Solomon, D.A., Waldman, T., Hieter, P. (2014). Glioblastoma cells containing mutations in the cohesin component STAG2 are sensitive to PARP inhibition. Mol Cancer Ther. 13(3):724-32.

Stirling, P.C., Shen, Y., Corbett, R., Jones, S.J., Hieter, P. (2014). Genome destabilizing mutator alleles drive specific mutational trajectories in Saccharomyces cerevisiae. Genetics 196(2):403-12.

Sajesh, B.V., Bailey, M., Lichtensztejn, Z., Hieter, P., McManus, K.J. (2013). Synthetic lethal targeting of superoxide dismutase 1 selectively kills RAD54B-deficient colorectal cancer cells. Genetics 195(3):757-67.

Bhavsar, A.P., Brown, N.F., Stoepel, J., Wiermer, M., Martin, D.D., Hsu, K.J., Imami, K., Ross, C.J., Hayden, M.R., Foster, L.J., Li, X., Hieter, P., Finlay, B.B. (2013). The Salmonella type III effector SspH2 specifically exploits the NLR co-chaperone activity of SGT1 to subvert immunity. PLoS Pathog. 9(7):e1003518.

Braberg, H., Jin, H., Moehle, E.A., Chan, Y.A., Wang, S., Shales, M., Benschop, J.J., Morris, J.H., Qiu, C., Hu, F., Tang, L.K., Fraser, J.S., Holstege, F.C., Hieter, P., Guthrie, C., Kaplan, C.D., Krogan, N.J. (2013). From structure to systems: high-resolution, quantitative genetic analysis of RNA polymerase II. Cell 154(4):775-88.

Price, J.C., Pollock, L.M., Rudd, M.L., Fogoros, S.K., Mohamed, H., Hanigan, C.L., Le Gallo, M., Program, N.I., Zhang, S., Cruz, P., Cherukuri, P.F., Hansen, N.F., McManus, K.J,. Godwin, A.K., Sgroi, D.C., Mullikin, J.C., Merino, M.J., Hieter, P., Bell, D.W. (2013). Sequencing of candidate chromosome instability genes in endometrial cancers reveals somatic mutations in ESCO1, CHTF18, and MRE11A. PLoS One 8(6):e63313.

Jinks-Robertson, S., Hieter, P. (2013). The 2013 Thomas Hunt Morgan Medal: Thomas Douglas Petes. Genetics 194(1):1-4.

van Pel, D.M., Stirling, P.C., Minaker, S.W., Sipahimalani, P., Hieter, P. (2013). Saccharomyces cerevisiae genetics predicts candidate therapeutic genetic interactions at the mammalian replication fork. G3 (Bethesda) 3(2):273-82.

van Pel, D.M., Barrett, I.J., Shimizu, Y., Sajesh, B.V., Guppy, B.J., Pfeifer, T., McManus, K.J., Hieter, P. (2013). An evolutionarily conserved synthetic lethal interaction network identifies FEN1 as a broad-spectrum target for anticancer therapeutic development. PLoS Genet. 9(1):e1003254.

O’Neil, N.J., van Pel, D.M., Hieter, P. (2013). Synthetic lethality and cancer: cohesin and PARP at the replication fork. Trends Genet. 29(5):290-7.

Minaker, S.W., Filiatrault, M.C., Ben-Aroya, S., Hieter, P., Stirling, P.C. (2013). Biogenesis of RNA polymerases II and III requires the conserved GPN small GTPases in Saccharomyces cerevisiae. Genetics 193(3):853-64.

Le Gallo, M., O’Hara, A.J., Rudd, M.L., Urick, M.E., Hansen, N.F., O’Neil, N.J., Price, J.C., Zhang, S., England, B.M., Godwin, A.K., Sgroi, D.C.; NIH Intramural Sequencing Center (NISC) Comparative Sequencing Program, Hieter, P., Mullikin, J.C., Merino, M.J., Bell, D.W. (2012). Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes. Nat Genet. 44(12):1310-5.

McLellan, J.L., O’Neil, N.J., Barrett, I., Ferree, E., van Pel, D.M., Ushey, K., Sipahimalani, P., Bryan, J., Rose, A.M., Hieter, P. (2012). Synthetic lethality of cohesins with PARPs and replication fork mediators. PLoS Genet. 8(3):e1002574.

Stirling, P.C., Chan, Y.A., Minaker, S.W., Aristizabal, M.J., Barrett, I., Sipahimalani, P., Kobor, M.S., Hieter, P. (2012). R-loop-mediated genome instability in mRNA cleavage and polyadenylation mutants. Genes Dev. 26(2):163-75.

Stirling, P.C., Crisp, M.J., Basrai, M.A., Tucker, C.M., Dunham, M.J., Spencer, F.A., Hieter, P. (2012). Mutability and mutational spectrum of chromosome transmission fidelity genes. Chromosoma 121(3):263-75.

Johnston, M., Andrews, B.J., Hawley, R.S., Sternberg, P.W., Hieter, P., Schedl, T. (2011). G3, GENETICS, and the GSA: Two Journals, One Mission. Genetics 189(1):1-2.

Andrews, B.J., Johnston, M., Hawley, R.S., Sternberg, P.W., Hieter, P., Schedl, T. (2011). G3, GENETICS, and the GSA: Two Journals, One Mission. G3 (Bethesda) 1(4):245-6.

Bell, D.W., Sikdar, N., Lee, K.Y., Price, J.C., Chatterjee, R., Park, H.D,. Fox, J., Ishiai, M., Rudd, M.L., Pollock, L.M., Fogoros, S.K., Mohamed, H., Hanigan, C.L.; NISC Comparative Sequencing Program, Zhang, S., Cruz, P., Renaud, G., Hansen, N.F., Cherukuri, P.F., Borate, B., McManus, K.J., Stoepel, J., Sipahimalani, P., Godwin, A.K., Sgroi, D.C., Merino, M.J., Elliot, G., Elkahloun, A., Vinson, C., Takata, M., Mullikin, J.C., Wolfsberg, T.G., Hieter, P., Lim, D.S., Myung, K. (2011). Predisposition to cancer caused by genetic and functional defects of mammalian Atad5. PLoS Genet. 7(8):e1002245.

Stirling, P.C., Bloom, M.S., Solanki-Patil, T., Smith, S., Sipahimalani, P., Li, Z., Kofoed, M., Ben-Aroya, S., Myung, K., Hieter, P. (2011). The complete spectrum of yeast chromosome instability genes identifies candidate CIN cancer genes and functional roles for ASTRA complex components. PLoS Genet. 7(4):e1002057.

Davies, A.H., Barrett, I., Pambid, M.R., Hu, K., Stratford, A.L., Freeman, S., Berquin, I.M., Pelech, S., Hieter, P., Maxwell, C., Dunn, S.E. (2011). YB-1 evokes susceptibility to cancer through cytokinesis failure, mitotic dysfunction and HER2 amplification. Oncogene 30(34):3649-60.

Fridman, Y., Palgi, N., Dovrat, D., Ben-Aroya, S., Hieter, P., Aharoni, A. (2010). Subtle alterations in PCNA-partner interactions severely impair DNA replication and repair. PLoS Biol. 8(10):e1000507.

Ben-Aroya, S., Pan, X., Boeke, J.D., Hieter, P. (2010). Making temperature-sensitive mutants. Methods Enzymol. 470:181-204.

Ben-Aroya, S., Agmon, N., Yuen, K., Kwok, T., McManus, K., Kupiec, M., Hieter, P. (2010). Proteasome nuclear activity affects chromosome stability by controlling the turnover of Mms22, a protein important for DNA repair. PLoS Genet. 6(2):e1000852.

McLellan, J., O’Neil, N., Tarailo, S., Stoepel, J., Bryan, J., Rose, A., Hieter, P. (2009). Synthetic lethal genetic interactions that decrease somatic cell proliferation in Caenorhabditis elegans identify the alternative RFC CTF18 as a candidate cancer drug target. Mol Biol Cell 20(24):5306-13.

McManus, K.J., Barrett, I.J., Nouhi, Y., Hieter, P. (2009). Specific synthetic lethal killing of RAD54B-deficient human colorectal cancer cells by FEN1 silencing. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3276-81.

Rogic, S., Montpetit, B., Hoos, H.H., Mackworth, A.K., Ouellette, B.F., Hieter, P. (2008). Correlation between the secondary structure of pre-mRNA introns and the efficiency of splicing in Saccharomyces cerevisiae. BMC Genomics 9:355.

Ben-Aroya, S., Coombes, C., Kwok, T., O’Donnell, K.A., Boeke, J.D., Hieter, P. (2008). Toward a comprehensive temperature-sensitive mutant repository of the essential genes of Saccharomyces cerevisiae. Mol Cell 30(2):248-58.

Barber, T.D., McManus, K., Yuen, K.W., Reis, M., Parmigiani, G., Shen, D., Barrett, I., Nouhi, Y., Spencer, F., Markowitz, S., Velculescu, V.E., Kinzler, K.W., Vogelstein, B., Lengauer, C., Hieter, P. (2008). Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers. Proc Natl Acad Sci U S A. 105(9):3443-8.

Yuen, K.W., Warren, C.D., Chen, O., Kwok, T., Hieter, P., Spencer, F.A. (2007). Systematic genome instability screens in yeast and their potential relevance to cancer. Proc Natl Acad Sci U S A. 104(10):3925-30.

Collins, S.R., Miller, K.M., Maas, N.L., Roguev, A., Fillingham, J., Chu, C.S., Schuldiner, M., Gebbia, M., Recht, J., Shales, M., Ding, H., Xu, H., Han, J., Ingvarsdottir, K., Cheng, B., Andrews, B., Boone, C., Berger, S.L., Hieter, P., Zhang, Z., Brown, G.W., Ingles, C.J., Emili, A., Allis, C.D., Toczyski, D.P., Weissman, J.S., Greenblatt, J.F., Krogan, N.J. (2007). Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Nature 446(7137):806-10.