Our lab is interested in the regulation of metabolism and of stress responses. In particular, we study how transcriptional regulators adapt genome transcription in response to nutritional cues and various types of stress. These metabolic and stress response pathways are of great biomedical relevance. For example, transcriptional activation of stress response programs helps cancers to grow in hostile microenvironments featuring oxidative stress, starvation, and hypoxia; vice versa, these pathways represent promising pharmacological targets to attack the cancer. To delineate genes and pathways that regulate stress and metabolism, we use the nematode Caenorhabditis elegans, the mouse, and cancer cell lines as genetically tractable models.
- Stress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stress. Ho N, Yap WS, Xu J, Wu H, Koh JH, Goh WWB, George B, Chong SC, Taubert S, Thibault G. J Cell Biol. 2020 Jul 6;219(7).
- Mediator subunit MDT-15/MED15 and Nuclear Receptor HIZR-1/HNF4 cooperate to regulate toxic metal stress responses in Caenorhabditis elegans. Shomer N, Kadhim AZ, Grants JM, Cheng X, Alhusari D, Bhanshali F, Poon AF, Lee MYY, Muhuri A, Park JI, Shih J, Lee D, Lee SV, Lynn FC, Taubert S. PLoS Genet. 2019 Dec 9;15(12):e1008508.
- NHR-49/HNF4 integrates regulation of fatty acid metabolism with a protective transcriptional response to oxidative stress and fasting. Goh GYS, Winter JJ, Bhanshali F, Doering KRS, Lai R, Lee K, Veal EA, Taubert S. Aging Cell. 2018 Jun;17(3):e12743.
- Activation of the endoplasmic reticulum unfolded protein response by lipid disequilibrium without disturbed proteostasis in vivo. Hou NS, Gutschmidt A, Choi DY, Pather K, Shi X, Watts JL, Hoppe T, Taubert S. PNAS. 2014 Jun 3;111(22):E2271-80.u