We use genome-scale screens and molecular cell biology approaches in model organisms and mammalian cells to study how proteins are localized to cellular membranes, and how defects in this process results in neurodegeneration and cancer.
Characterization of the stem cell state and its control by comparative global gene expression and proteomics analyses.
Molecular biology of eukaryotic chromosome transmission, cancer therapeutics, model organism and human disease.
Gene regulation, leukemic stem cell biology, basic and translational leukemia research, signal transduction, proteomics.
Bioinformatics, gene expression, gene regulation, genome sequence analysis and genome assembly.
Stem cells, developmental control, telomere biology, self-renewal and genetic instability.
Gene regulatory changes in malignancy, ribosomal variation in cancer, impact of transposable elements on mammalian genes.
Immune response to cancer; immunogenomics; adoptive T cell therapy; T cell engineering; oncolytic viruses; phase I clinical trials
Genome maintenance, DNA repair, RNA processing, DNA replication stress, Chromatin Remodelling, Stress responses, Protein quality control, Genotoxins, Saccharomyces cerevisiae, Mutation Signatures.